Transfusion-associated Graft-versus-Host Disease (TA-GVHD) is a big deal. In this episode, hear why we should be looking for TA-VGHD in unexpected places!
Dr. Joe Chaffin
Unexpected Cases
However, a paper from authors in Canada published in July 2015 (see below for reference) summarizing all of the published reports of this deadly complication makes us wonder if we really do understand this devastating complication as well as we believed. In this episode, I start from the basics and outline the details of TA-GVHD, and discuss the implications of the information found in the review mentioned above.
For More Details…
Note that I don’t discuss the details of irradiation that much in this episode. For more on irradiation and how it works, please check out my discussion on irradiation with Chris Tormey in episode 074 of this podcast, as well as my “Ten Minute Tutorial” video on irradiation.
Dr. Joe Chaffin
Unexpected Cases
However, a paper from authors in Canada published in July 2015 (see below for reference) summarizing all of the published reports of this deadly complication makes us wonder if we really do understand this devastating complication as well as we believed. In this episode, I start from the basics and outline the details of TA-GVHD, and discuss the implications of the information found in the review mentioned above.
For More Details…
Note that I don’t discuss the details of irradiation that much in this episode. For more on irradiation and how it works, please check out my discussion on irradiation with Chris Tormey in episode 074 of this podcast, as well as my “Ten Minute Tutorial” video on irradiation.
DISCLAIMER: The opinions expressed on this episode are those of my guest and I alone, and do not reflect those of the organizations with which either of us is affiliated. Neither Dr. Shafi nor I have any relevant financial disclosures.
Time-Stamped Notes
- 01:40: Meet the new co-host, Dr. Heidi Shafi!
- 05:15: The “Ask BBGuy” Question for this episode
- 06:45: What is “graft-versus-host disease?”
- 08:20: Requirements for GVHD
- 12:25: TA-GVHD: How is it different from “regular” GVHD?
- 22:08: Normal interactions between transfused and host T-lymphocytes (Soldiers and Pac-men)
- 25:20: What goes wrong in TA-GVHD?
- 31:25: Who is at-risk for TA-GVHD?
- 45:10: Other categories potentially at-risk
- 50:15: TA-GVHD treatment and grim prognosis
- 53:05: What’s the deal with irradiation?
- 56:05: Irradiation changes to product expiration time
- 57:20: Which products need irradiation?
- 58:55: Why isn’t leukocyte reduction enough?
- 61:30: Pathogen reduction benefit for preventing TA-GVHD
- 62:45: Discussion of Kopolovic article listed below
this podcast is superb.Listened about 3 times as so much informative information, loved Dr Shafi’s down to earth questions. I enjoyed the discussion on the paper particularly as I generally find reading papers excruciating difficult as I am not a true scientist and my mind wanders. Would you ever consider doing a podcast on how to read a paper for beginners? and explain prospective retrospective etc etc. Do you guys really understand all those mathematical stats. Even better discuss with us in your wonderful manner current hot papers?
Amanda, thank you for the kind words! Dr. Shafi is awesome, and I’m lucky to have her as my co-host. Thanks for the topic suggestion, as well. I might do that at some point. Best to you!
Joe
Hi,
I’m a medical laboratory science student, and I’m very grateful to Dr. Shaffin for clear explanation. This is the best explanation I’ve read, because you can see how it going in normal situation, and what is wrong in case of disease. When I watched video only about TA-GvHD, it was not so obvious. Comparison fixed this problem.
Thank you , very much!
Sincerely,
Elena.
I’m very glad it was helpful to you, Elena!
-Joe
Hello Dr. Chaffin,
Thanks for all the excellent teachings you provide for us.
Here are my questions;
Irradiation for neonate, do you mean(1-30 days) of age? To protect kids, at what age T cells function like adult T cells? 4-7 year old?
TA-GVHD in liver, can we detect the transfused lymphocytes by chimerism studies (STR)?
Thank you